Variable structure techniques in control system design

During the last twenty years, control theorists belonging almost exclusively to the USSR, have laid down the foundations of variable-structure systems (commonly abbreviated to vsS). As the name implies, such systems are allowed to change their structure through time in accordance with some preassigned algorithm. The theory has demonstrated that some significant advantages could be gained by adopting that approach in the, design of automatic control systems, amongst which are good transient responses and insensitivity to parametric variations and to external disturbances. The VS controller is slightly more complex than a fixed structure design based on standard methods such as state feedback or frequency response techniques, but is a great deal less complex than some adaptive designs. It also lends itself to a straightforward microcomputer implementation. While the theoretical aspect of VSS has been well explored, its general applicability to engineering problems is yet to be established. There are still unanswered questions as to the suitability of the method for practical systems, which invariably contain a certain amount of noise, uncertainties and nonlinearities. The work described in this thesis concentrates on that particular aspect and is, in brief, an investigation of VSS as an engineering design procedure. The theory of VSS is reviewed and the principles are then applied to a number of engineering examples. The performance of the systems are assessed from digital simulation runs, hybrid computation and the microcomputer control of a DC motor

Impact of Sb and Na Doping on the Surface Electronic Landscape of Cu2ZnSnS4 Thin Films

Open-circuit voltage deficiency is the key limiting factor in Cu2ZnSnS4 (CZTS) thin-film solar cells, which is commonly associated with band tails and deep gap states arising from elemental disorder. The introduction of dopants such as Na and Sb has led to improvement in device performance, yet their effects on the optoelectronic properties of CZTS are yet to be fully elucidated. In this Letter, we unraveled the effect of Sb and Na:Sb co-doping on the surface energy landscape of solution-processed CZTS films employing energy-filtered photoelectron emission microscopy. In the absence of the additives, 150 nm resolution photoemission maps reveal oscillations in the local effective work function as well as areas of low photoemission energy threshold. The introduction of dopants substantially reshapes the photoemission maps, which we rationalize in terms of Cu:Zn and Sn disorder. Finally, we establish unprecedented correlations between the photoemission landscape of thin films and the performance of over 200 devices

Matriarch: A Python Library for Materials Architecture

Biological materials, such as proteins, often have a hierarchical structure ranging from basic building blocks at the nanoscale (e.g., amino acids) to assembled structures at the macroscale (e.g., fibers). Current software for materials engineering allows the user to specify polypeptide chains and simple secondary structures prior to molecular dynamics simulation, but is not flexible in terms of the geometric arrangement of unequilibrated structures. Given some knowledge of a larger-scale structure, instructing the software to create it can be very difficult and time-intensive. To this end, the present paper reports a mathematical language, using category theory, to describe the architecture of a material, i.e., its set of building blocks and instructions for combining them. While this framework applies to any hierarchical material, here we concentrate on proteins. We implement this mathematical language as an open-source Python library called Matriarch. It is a domain-specific language that gives the user the ability to create almost arbitrary structures with arbitrary amino acid sequences and, from them, generate Protein Data Bank (PDB) files. In this way, Matriarch is more powerful than commercial software now available. Matriarch can be used in tandem with molecular dynamics simulations and helps engineers design and modify biologically inspired materials based on their desired functionality. As a case study, we use our software to alter both building blocks and building instructions for tropocollagen, and determine their effect on its structure and mechanical properties.Center for Excellence in Education. Research Science InstituteUnited States. Office of Naval Research. Presidential Early Career Award for Scientists and Engineers (N000141010562)United States. Air Force. Office of Scientific Research (FA9550-11-1-0199)United States. Army Research OfficeNational Institutes of Health (U.S.) (5U01EB016422)National Institutes of Health (U.S.) (EB014976)BASF. North American Center for Research on Advanced Material

The Interior of Jupiter

Jupiter, owing to its large mass and rapid formation, played a crucial role in shaping the solar system as we know it today. Jupiter mostly contains hydrogen and helium (more than 87% by mass), and as such bears a close resemblance to the Sun. However, the Sun has only 2% of its mass in elements other than hydrogen and helium (the heavy elements), whereas Jupiter has between 3 and 13%. The exact amount of these heavy elements in the planet and their distribution are keys to understanding how the solar system formed

Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D.

Acne vulgaris is the most common skin disorder affecting millions of people worldwide and inflammation resulting from the immune response targeting Propionibacterium acnes has a significant role in its pathogenesis. In this study, we have demonstrated that P. acnes is a potent inducer of T helper 17 (Th17) and Th1, but not Th2 responses in human peripheral blood mononuclear cells (PBMCs). P. acnes stimulated expression of key Th17-related genes, including IL-17A, RORα, RORc, IL-17RA, and IL-17RC, and triggered IL-17 secretion from CD4(+), but not from CD8(+) T cells. Supernatants from P. acnes-stimulated PBMCs were sufficient to promote the differentiation of naive CD4(+)CD45RA T cells into Th17 cells. Furthermore, we found that the combination of IL-1β, IL-6, and transforming growth factor-β-neutralizing antibodies completely inhibited P. acnes-induced IL-17 production. Importantly, we showed that IL-17-expressing cells were present in skin biopsies from acne patients but not from normal donors. Finally, vitamin A (all-trans retinoic acid) and vitamin D (1,25-dihydroxyvitamin D3) inhibited P. acnes-induced Th17 differentiation. Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne

Storms and the Depletion of Ammonia in Jupiter: I. Microphysics of “Mushballs”

Microwave observations by the Juno spacecraft have shown that, contrary to expectations, the concentration of ammonia is still variable down to pressures of tens of bars in Jupiter. We show that during strong storms able to loft water ice into a region located at pressures between 1.1 and 1.5 bar and temperatures between 173 and 188 K, ammonia vapor can dissolve into water ice to form a low‐temperature liquid phase containing about one‐third ammonia and two‐third water. We estimate that, following the process creating hailstorms on Earth, this liquid phase enhances the growth of hail‐like particles that we call mushballs. We develop a simple model to estimate the growth of these mushballs, their fall into Jupiter’s deep atmosphere, and their evaporation. We show that they evaporate deeper than the expected water cloud base level, between 5 and 27 bar depending on the assumed abundance of water ice lofted by thunderstorms and on the assumed ventilation coefficient governing heat transport between the atmosphere and the mushball. Because the ammonia is located mostly in the core of the mushballs, it tends to be delivered deeper than water, increasing the efficiency of the process. Further sinking of the condensates is expected due to cold temperature and ammonia‐ and water‐rich downdrafts formed by the evaporation of mushballs. This process can thus potentially account for the measurements of ammonia depletion in Jupiter’s deep atmosphere.Plain Language SummaryThe Juno mission has revealed that Jupiter’s atmosphere is much more complex and intriguing than previously anticipated. Most of Jupiter’s atmosphere was shown to be depleted in ammonia. While ammonia was expected to be well mixed, large scale variability of ammonia was detected at least 100 km below the cloud level where condensation occurs. We propose a mechanism to explain this depletion and variability. We show that in Jupiter, at very low temperatures (of order −90° C), water ice and ammonia vapor combine to form a liquid and we hypothesize that this subsequently triggers unexpected meteorology. During Jupiter’s violent storms, hailstones form from this liquid, similar to the process in terrestrial storms where hail forms in the presence of supercooled liquid water. Growth of the hailstones creates a slush‐like substance surrounded by a layer of ice, and these “mushballs” fall, evaporate, and continue sinking further in the planet’s deep atmosphere, creating both ammonia depletion and variability, potentially explaining the Juno observations.Key PointsWe show that ammonia can melt water‐ice crystals in Jupiter’s storms and lead to the formation of water‐ammonia hailstones (mushballs)These mushballs and subsequent downdrafts transport ammonia to very deep levelsThis can potentially explain Juno measurements that Jupiter’s ammonia abundance is variable until at least 150 km below the visible cloudsPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156131/2/jgre21375.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156131/1/jgre21375_am.pd

Identification and Characterisation of an Iron-Responsive Candidate Probiotic

Background: Iron is an essential cofactor in almost all biological systems. The lactic acid bacteria (LAB), frequently employed as probiotics, are unusual in having little or no requirement for iron. Iron in the human body is sequestered by transferrins and lactoferrin, limiting bacterial growth. An increase in the availability of iron in the intestine by bleeding, surgery, or under stress leads to an increase in the growth and virulence of many pathogens. Under these high iron conditions, LAB are rapidly out-competed; for the levels of probiotic bacteria to be maintained under high iron conditions they must be able to respond by increasing growth rate to compete with the normal flora. Despite this, iron-responsive genera are poorly characterised as probiotics. Methodology/Principal Findings: Here, we show that a panel of probiotics are not able to respond to increased iron availability, and identify an isolate of Streptococcus thermophilus that can increase growth rate in response to increased iron availability. The isolate of S. thermophilus selected was able to reduce epithelial cell death as well as NF-kB signalling and IL-8 production triggered by pathogens. It was capable of crossing an epithelial cell barrier in conjunction with E. coli and downregulating Th1 and Th17 responses in primary human intestinal leukocytes. Conclusions/Significance: We propose that an inability to compete with potential pathogens under conditions of high iron availability such as stress and trauma may contribute to the lack of efficacy of many LAB-based probiotics in treatin

Phase II prospective randomized trial of weight loss prior to radical prostatectomy.

BACKGROUND:Obesity is associated with poorly differentiated and advanced prostate cancer and increased mortality. In preclinical models, caloric restriction delays prostate cancer progression and prolongs survival. We sought to determine if weight loss (WL) in men with prostate cancer prior to radical prostatectomy affects tumor apoptosis and proliferation, and if WL effects other metabolic biomarkers. METHODS:In this Phase II prospective trial, overweight and obese men scheduled for radical prostatectomy were randomized to a 5-8 week WL program consisting of standard structured energy-restricted meal plans (1200-1500 Kcal/day) and physical activity or to a control group. The primary endpoint was apoptotic index in the radical prostatectomy malignant epithelium. Secondary endpoints were proliferation (Ki67) in the radical prostatectomy tissue, body weight, body mass index (BMI), waist to hip ratio, body composition, and serum PSA, insulin, triglyceride, cholesterol, testosterone, estradiol, leptin, adiponectin, interleukin 6, interleukin 8, insulin-like growth factor 1, and IGF binding protein 1. RESULTS:In total 23 patients were randomized to the WL intervention and 21 patients to the control group. Subjects in the intervention group had significantly more weight loss (WL:-3.7 ± 0.5 kg; Control:-1.6 ± 0.5 kg; p = 0.007) than the control group and total fat mass was significantly reduced (WL:-2.1 ± 0.4; Control: 0.1 ± 0.3; p = 0.015). There was no significant difference in apoptotic or proliferation index between the groups. Among the other biomarkers, triglyceride, and insulin levels were significantly decreased in the WL compared with the control group. CONCLUSIONS:In summary, this short-term WL program prior to radical prostatectomy resulted in significantly more WL in the intervention vs. the control group and was accompanied by significant reductions in body fat mass, circulating triglycerides, and insulin. However, no significant changes were observed in malignant epithelium apoptosis or proliferation. Future studies should consider a longer term or more intensive weight loss intervention